Background: This study aimed to investigate the reliability and validity of the Iranian version of the Pediatric\r\nQuality of Life Inventoryââ??¢ 4.0 (PedsQLââ??¢ 4.0) Generic Core Scales in children.\r\nMethods: A standard forward and backward translation procedure was used to translate the US English version of\r\nthe PedsQLââ??¢ 4.0 Generic Core Scales for children into the Iranian language (Persian). The Iranian version of the\r\nPedsQLââ??¢ 4.0 Generic Core Scales was completed by 503 healthy and 22 chronically ill children aged 8-12 years\r\nand their parents. The reliability was evaluated using internal consistency. Known-groups discriminant comparisons\r\nwere made, and exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted.\r\nResults: The internal consistency, as measured by Cronbachââ?¬â?¢s alpha coefficients, exceeded the minimum reliability\r\nstandard of 0.70. All monotrait-multimethod correlations were higher than multitrait-multimethod correlations. The\r\nintraclass correlation coefficients (ICC) between the children self-report and parent proxy-reports showed moderate\r\nto high agreement. Exploratory factor analysis extracted six factors from the PedsQLââ??¢ 4.0 for both self and proxy\r\nreports, accounting for 47.9% and 54.8% of total variance, respectively. The results of the confirmatory factor\r\nanalysis for 6-factor models for both self-report and proxy-report indicated acceptable fit for the proposed models.\r\nRegarding health status, as hypothesized from previous studies, healthy children reported significantly higher\r\nhealth-related quality of life than those with chronic illnesses.\r\nConclusions: The findings support the initial reliability and validity of the Iranian version of the PedsQLââ??¢ 4.0 as a\r\ngeneric instrument to measure health-related quality of life of children in Iran.
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